- Nemesis System – creatures that kill you now ascend and stalk the afterlife on their own terms. Gaining new perks and abilities.
- Nemesis creatures from previous games can spawn in new games
- Nemesis creatures have their own name and appear with stars around them
- Nemesis creatures that slay you again continue to advance
- Updating AI to be ability aware so if it gains new perks it will use them appropriately
- Perks that grant ranged or melee abilities to creatures now ensure they have basic ranged or melee capabilities (Zombies with shotguns actually use the shotgun)
- Creatures will no longer gain perks that would not apply, such as regeneration